Iopidine 0.5% 5 ml

Before you start taking Iopidine, you need to consult with your doctor and determine the ptosis area after Botox injections. Inexperienced specialists often confuse upper eyelid ptosis with eyebrow ptosis.

With eyebrow ptosis, Iopidine therapy may be completely useless. You see, these pathologies involve different muscle fibers. Therefore, self-treatment is not the best solution in case of eyelid ptosis.

Perhaps, a Botox injection caused an allergic reaction, such as swelling of the eyebrows and eyelids. In this case, the use of Iopidine is impractical. It is advisable to take an antihistamine as soon as possible. Therefore, you should consult a doctor or an aesthetic practitioner, who did the procedure in the first place to get a correct diagnosis.

Is there an alternative to Iopidine eye drops?

The pharmaceutical market offers a large number of drugs, which reduce the intraocular pressure, such as:

  • Bimatoprost,
  • Clonidine,
  • Timolol.

Therefore, Iopidine eye drops have many alternatives for glaucoma treatment.

However, if you consider this product as a remedy for ptosis of the upper eyelid, there is practically no alternative to it.

The fact is that too little attention is put on this cosmetic defect. In the pharmaceutical market, you can find only 1-2 effective drugs.

At that, ptosis is a rather dangerous pathology. It can cause strabismus, eye irritation and many other complications. For a long time, surgery was used, if a threat of complications manifested. The eyelid was attached to the frontal muscle, and the problem was solved.

Iopidine is an innovative product. This is the first drug, which can help you return the upper eyelid to its natural position in a couple of weeks. At the same time, it practically does not matter, what caused the eyelid ptosis. There are only a couple of pathologies, in which this product cannot help. Most often, these are genetic abnormalities, which are solved by operational methods only.


Iopidine has gained extraordinary popularity in cosmetic practice in recent years due to its ability to restore the function of the internal muscles of the upper eyelid. It increases the tone of the ciliary muscle of the eye and causes the rise of the upper eyelid in ptosis.

This is due to the selective stimulation of alpha-2-adrenoreceptors in the Muller’s muscle. This muscle connects with smooth muscle fibers, responsible for lifting the upper eyelid.

Iopidine is a brand name for the active ingredient Apraclonidine hydrochloride. It is a selective alpha-2 adrenostimulator with a pronounced hypotensive effect.

The drug Iopidine effectively reduces intraocular pressure in glaucoma. Unlike analogs, Apraclonidine has no systemic effect. This explains its good tolerability and low frequency of side effects.

How does Iopidine work?

The active ingredient Apraclonidine hydrochloride is responsible for the pharmacological action of the drug Iopidine. This substance has a triple mechanism:

  1. Reduces the production of aqueous humor in the eye
  2. Increases uveoscleral outflow
  3. Stimulates the contraction of the ciliary muscles of the eye (in particular the circular fibers)

In plain words, Iopidine prevents intraocular fluid from concentrating in the anterior and posterior chamber of the eye. This reduces the constant resistance inside the eye, which causes a decrease in vision and pain.

Indications for use

  • Ptosis of the upper eyelid (both in pathological changes in the Muller’s muscles and after injections of botulinum toxin).
  • Increased intraocular pressure (glaucoma)


  1. Raises the upper eyelid with ptosis.
  2. Works in almost all forms of ptosis of the upper eyelid.
  3. Stimulates adrenoreceptors selectively. Does not create an additional burden on the heart in healthy people.
  4. Does not provide a sedative effect.
  5. Is allowed to use even with normal intraocular pressure.

Drug form and composition

  • Iopidine is produced in the form of eye drops, in bottles of 5 ml;
  • The concentration of Apraclonidine hydrochloride in the solution is 5.75 mg per 1 ml.

Eye drops are a sterile isotonic solution. As excipients, it contains sodium chloride, purified water, sodium acetate, sodium hydroxide, benzalkonium chloride. These are inactive substances, which do not provide any pharmacological action.

Mode of administration

Iopidine 0.5 eye drops are used 2-3 times a day, with an interval of not more than 6-8 hours.

In 8 hours after the administration of the eye drops, the active substance becomes less active. To maximize the effect, follow the administration regimen for Iopidine.

  • Iopidine 0.5% is administered in just 1 drop in the eye, in which the eyelid is lowered.
  • With the inefficiency of the standard regimen, Iopidine 0.5 is administered in 2 drops in each eye, 3 times a day.
  • Iopidine begins to work 60 minutes after the administration and reaches its peak in a maximum of 3 hours.

Your doctor should prescribe an individualized dosage of Iopidine. If after 2-3 weeks you did not manage to lift the upper eyelid, the further intake of drops is inexpedient. It is necessary to undergo additional examination and find the cause of the omission of the century. Perhaps ptosis is not caused by a dysfunction of Muller.

If the treatment is successful, Iopidine drops should not be used for more than 4 weeks. In rare cases, therapy lasts up to 6 weeks.

Ptosis of the upper eyelid after Botox injections can also occur on its own. It takes 3-4 months. When taking Iopidine eye drops, you will be able to restore the position of the century in just 1-1.5 months.

Precautionary measures

  • Iopidine should not be taken in patients who have had a myocardial infarction or stroke in the last 3-6 months.
  • Apraclonidine is strictly contraindicated in patients with uncontrolled arterial hypertension.
  • While taking Iopidine drops, you must stop using MAO inhibitors, tricyclic antidepressants and norepinephrine stimulants.
  • Iopidine is not recommended for use by persons under 18 years of age, women during pregnancy and lactation.

Iopidine Side effects

When Iopidine 0.5 is used in low doses, the chance of side effects is very low. In most patients, treatment proceeds without discomfort and unwanted symptoms.

The probability of complications increases when you use the eye drops more than 4 times a day.

During clinical trials, it was found that about 16% of people have hypersensitivity to Iopidine, which manifests itself in the form of the following symptoms:

  • Profuse tearing
  • Dry mouth
  • Redness of the eyelids
  • Slight itchy eyelid skin
  • Feeling of discomfort in the eyes
  • Dizziness
  • Headache
  • Contact dermatitis

Cardiovascular side effects were observed in less than 2% of patients on Iopidine, and these are:

  • Cardiopalmus,
  • Blood pressure increase

These symptoms occur most often in patients with chronic cardiovascular diseases. To avoid them, you can reduce the daily dose of Iopidine.

When the allergic reaction to this medication appears, you should immediately stop using the drug and consult a doctor.


The price of Iopidine 0.5% in major pharmacies in the United States reaches $ 180 for 1 bottle of 5 ml.

Health insurance covers part of the cost of eye drops only if you have a prescription from a doctor. Your doctor will only be able to issue a prescription for Iopidine, if you have signs of glaucoma.

If you suffer from ptosis of the upper eyelid after a botulinum toxin injection, you are likely not to get a prescription from a doctor. The eyelid should rise within a few months without medication. Therefore, doctors rarely prescribe medication for ptosis, if the disease does not threaten the person's vision.

However, even with a prescription, insurance does not cover the entire cost of eye drops. Iopidine cost with insurance will be about $ 90-120, depending on the pharmacy and the type of insurance you have. It is still more expensive than we offer.

We offer you to buy Iopidine 0.5% at a price of $ 60 per 5 ml bottle. This is the original Apraclonidine hydrochloride, which is delivered to our warehouse from the manufacturing plant. We do not cooperate with intermediaries, who set a high margin. Therefore, wholesale prices for this product are valid for our customers.

On our site, you can buy iopidine drops over the counter in any country in the world. Parcel delivery takes 5 days.

  • Express delivery takes 5 working days, and the courier will deliver your package to your home or work.

To pay for the purchase of Iopidine online, you can use a credit card or Bitcoin. If you have questions about the delivery or payment of the order, please contact our consultant. He will answer all your questions and help you place your order correctly.

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Iopidine 0.5% (Apraclonidine HCL) Sterile Ophthalmic Solution

ManufacturerAlcon, Novartis
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